Elevated Kappa Light Chain Ratio

In the context of mgus or myeloma significantly increased free light chain production and a markedly abnormal kappa lambda ratio indicate an increased risk of disease progression.

Elevated kappa light chain ratio.

These unlinked chains are known as free light chains. Lambda light chain concentration range. The ratio or proportion between the kappa and lambda light chains indicates an excess production of one chain over the other and therefore can be used as an indication of disease progression or remission said dr. What else should i ask answered by dr.

A free light chains test measures the amount of lambda and kappa free light chains in the blood. The exact normal ratio of kappa to lambda according to a novel polyclonal free light chain assay ranges from 0 26 to 1 65. Epub 2015 jun 3. Lambda and kappa light chains.

Told me my kappa light chain is elevated at 26. 5 7 26 3 mg ml. Kappa light chain concentration range. Abnormal free light chain production has also been reported to be prognostic of a worse outcome in multiple myeloma and chronic lymphocytic leukaemia.

It is normal for there to be small fluctuations in the uninvolved light chain concentration over time which have no clinical significance at all. Authors aneta niewmierzycka. Increased lambda free light chains and a decreased kappa lambda ratio may be seen with plasma cell disorders that produce excess monoclonal lambda light chains. In a healthy individual the total kappa to lambda ratio is roughly 2 1 in serum measuring intact whole antibodies or 1 1 5 if measuring free light chains with a highly divergent ratio indicative of neoplasm.

She told me not to worry and we ll check again in 3 months. There are two types of light chains. An abnormal light chain ratio has been defined as a kappa to lambda chain ratio of less than 0 26 or more than 1 65. Prevalence and clinical significance of abnormal serum kappa lambda light chain ratio in patients with chronic kidney disease pol arch med wewn.

You have a minimal degree of change this may be wi. Normal values for kappa lambda and flc ratio.